JAMA Clinical Reviews

Ischemic stroke is a leading cause of disability and death and accounts for about 85% of strokes in the US. Author Gregory Albers, MD, of Stanford University Medical Center joins JAMA Deputy Editor Karen Lasser, MD, MPH, to discuss the diagnosis and treatment of ischemic stroke.

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Treatment of Acute Ischemic Stroke

Idiosyncratic drug-induced liver injury is damage caused by prescription or over-the-counter medications or herbal dietary supplements that is not dose-dependent. JAMA Associate Editor Beverly Forsyth, MD, speaks with author Naga Chalasani, MD, of Indiana University School of Medicine about risk factors, evaluation, and treatment of patients with idiosyncratic drug-induced liver injury.

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Idiosyncratic Drug-Induced Liver Injury
Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data

Childhood obesity affects approximately 15% of children aged 2 to 12 and is associated with adverse health outcomes in adulthood. Author Claudia K. Fox, MD, MPH, of the University of Minnesota Medical School joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss epidemiology, diagnosis, and treatment of childhood obesity.

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Obesity in Children Aged 2 to 12 Years

Heart transplant for patients with advanced heart failure can lead to improved survival and quality of life. Author JoAnne Lindenfeld, MD, of Vanderbilt University joins JAMA Associate Editor David Simel, MD, MHS, to discuss indications, transplant evaluation, management after transplant, long-term complications, and survival.

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Heart Transplant for Advanced Heart Failure

Narcolepsy is a chronic neurologic disorder that causes severe daytime sleepiness and impaired quality of life. Author Tom Scammell, MD, of Harvard Medical School joins JAMA Deputy Editor Karen Lasser, MD, MPH, to discuss the etiology, clinical presentation, diagnostic evaluation, and treatment of narcolepsy.

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Narcolepsy
The Orexin System—A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy