Genetics in Your World

In this episode of Genetics in Your World, GSA Early Career Scientist Multimedia Subcommittee member X has a conversation with Denise Ferkey of University at Buffalo about how natural variation in C. elegans responds to odors. Using hundreds of wild strains from the Caenorhabditis Natural Diversity Resource, the team found that wild worms were either as sensitive as the lab reference strain N2 to the aversive odorant 1-octanol or less so, and they traced this reduced avoidance to a single region on chromosome II. Read her paper titled, "Natural variation in C. elegans 1-octanol olfactory avoidance behavior," published in the October 2026 issue of G3: Genes|Genomes|Genetics: https://doi.org/10.1093/g3journal/jkag189. Hosted on Acast. See acast.com/privacy for more information.

In this episode of Genetics in Your World, GSA Early Career Scientist Multimedia Subcommittee co-chair Anindya Ganguly and member Racheal Asaolu interview Colin LaMont of University of Oslo. They discuss LaMont's work which presents a new mathematical method for calculating how strongly selection favors a genetic variant directly from an evolutionary tree, without knowledge of exact population history, finding that ancestral lineages act like strategists anticipating future selection rather than just responding to it in the moment. Read his paper titled, "Optimal control and the dynamics of ancestral lineages," published in the August 2026 issue of GENETICS: https://doi.org/10.1093/genetics/iyag122

Music: Loopster Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 License, http://creativecommons.org/licenses/by/3.0/

#PopGen #PopulationGenetics #NaturalSelection #phylogenetics #evolution #EvolutionaryDynamics
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In this episode of Genetics in Your World, GSA Early Career Scientists Multimedia Subcommittee member Racheal Asaolu has a conversation with Dr. Randall J. Roper of the School of Science at Indiana University. They discuss Roper's work. Read his paper titled, "Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice," published in the May 2026 issue of G3: Genes|Genomes|Genetics: https://doi.org/10.1093/g3journal/jkag056.

Music: Loopster Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 License, http://creativecommons.org/licenses/by/3.0/

Thank you to the Multimedia Subcommittee, particularly the production team for this episode: Racheal Asaolu, interviewer; Shruti Shastry, Audio Quality Control Coordinator; Laetitia Chauve and Anindya Ganguly, researchers.

#Trisomy21 #SkeletalDeficits #SexDifferences #MicroComputedTomography
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In this episode of Genetics in Your World, GSA Early Career Scientists Multimedia Subcommittee member Luke Arnce interviews Caitlin Peaslee of the Center for Embryonic Cell and Gene Therapy at Oregon Health and Science University about her research. Read her paper titled, "Mapping whole-organism genetic comorbidities across model species using unified ontologies," published in the April 2026 issue of GENETICS: https://doi.org/10.1093/genetics/iyag038

This study developed a cross-species computational framework, CoMo DBM, to analyze 204 mouse genes that caused non-obstructive azoospermia and mapped their phenotype associations across human, zebrafish, fruit fly, and roundworm databases.

Music: Loopster Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 License, http://creativecommons.org/licenses/by/3.0/

#GeneEditing #cancer #GeneOntology
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In this episode of Genetics in Your World, GSA Early Career Scientist Multimedia Subcommittee advisor Sarah Renee Phillips interviews Srishti Patil of the German Cancer Research Center and Dr. Robert Noble of City St. George's, University of London about their research. Read their paper titled, “Preventing evolutionary rescue in cancer using two-strike therapy,” published in the February 2026 issue of GENETICS: https://doi.org/10.1093/genetics/iyaf255.

Music: Loopster Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 License, http://creativecommons.org/licenses/by/3.0/

#evolution #cancer #GeneticRescue #variation #selection #mutation
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