PsychRounds: The Psychiatry Podcast

• Introduction to Benzodiazepines

  Today, we are talking about a very popular, yet controversial class of medications - the Benzodiazepines . Let's look at their mechanism of action, clinical indications, pharmacology, risks, withdrawal syndromes, and prescribing guidance. And of course, we'll be tackling the question: what are the risks and benefits of long-term use? References: https://pubmed.ncbi.nlm.nih.gov/30098211/https://pubmed.ncbi.nlm.nih.gov/32252539/https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rateshttps://aapp.org/guideline/benzohttps://pubmed.ncbi.nlm.nih.gov/40526204/https://pmc.ncbi.nlm.nih.gov/articles/PMC6097846/https://www.ncbi.nlm.nih.gov/books/NBK470159/https://www.cambridge.org/core/journals/advances-in-psychiatric-treatment/article/benzodiazepines-for-anxiety-disorders-maximising-the-benefits-and-minimising-the-risks/43A366723CD1B3616BAB08F69FF65A88

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• Introduction to Anxiety Disorders

  Welcome to an introductory episode on anxiety disorders as requested by a long-time listener. References:https://pmc.ncbi.nlm.nih.gov/articles/PMC5832062/https://pmc.ncbi.nlm.nih.gov/articles/PMC5573565/https://deepblue.lib.umich.edu/bitstream/handle/2027.42/175862/Nesse%20Anxiety%20Disorders%20in%20Evolutionary%20Perspective%202022.pdf?sequence=1

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• Loxapine (Loxitane) Revisited with Dr. Jonathan Meyer

  Join us as we talk about Loxapine, an older medication that’s stood the test of time and found a niche in psychiatric practice. This is a revision of an earlier episode, after Dr. Bradley Miller chatted with Dr. Jonathan Meyer at the 2025 APA Conference. Dr. Meyer joins us at the beginning to provide an addendum to the original episode.

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• Pregabalin (Lyrica)

  Welcome back! Today, we will be talking about Pregabalin, brand-name Lyrica, a similar medication to Gabapentin, and we will specifically be focusing on its use in psychiatry. What are its benefits and drawbacks compared to Gabapentin? Sources:- https://pubmed.ncbi.nlm.nih.gov/33563173/- https://pubmed.ncbi.nlm.nih.gov/39989902/- https://pmc.ncbi.nlm.nih.gov/articles/PMC3699256/- https://pubmed.ncbi.nlm.nih.gov/33563173/

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• Gabapentin (Neurontin)

  Welcome back! Today, we will be talking about Gabapentin, brand-name Neurontin, one of the most commonly-prescribed medications in the United States, and we will specifically be focusing on its use in psychiatry. It is commonly prescribed for anxiety disorders, alcohol use disorder, and sometimes even bipolar disorder! But what does the evidence say?Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC3619699/#:~:text=The%20FDA%20approved%20gabapentin%20enacarbil,legs%20syndrome%20(RLS)%20symptoms.https://journals.lww.com/intclinpsychopharm/Abstract/2017/01000/Pregabalin_for_generalized_anxiety_disorder__an.8.aspxhttps://pmc.ncbi.nlm.nih.gov/articles/PMC9507147/https://pmc.ncbi.nlm.nih.gov/articles/PMC4732322/https://pubmed.ncbi.nlm.nih.gov/9263379/https://pubmed.ncbi.nlm.nih.gov/28988943/https://www.cdc.gov/mmwr/volumes/71/wr/mm7119a3.htm

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