Editors in Conversation

• Static vs Cidal Antibiotics: Concepts Revisited

  A common description of antibiotic action aims to classify them between “bactericidal” or “bacteriostatic”. Although these phenomena have robust in vitro foundations, the clinical translation of these concepts is sometimes difficult to ascertain. This controversial topic has important conceptual ramifications to treat severe infections. Today, we will discuss this topic with an expert in field.  Watch the video version here: https://youtu.be/3z4BItBrzbk Topics discussed: The definitions of “cidal” vs “static” antibiotics The clinical applicability of the above terms in terms of antibiotic choice and syndromatic approaches antibiotic choices and the controversy between bactericidal and bacteriostatic antibiotics.  Guest: Brad Spellberg, MD.  Chief Medical Officer at the Los Angeles General Medical Center  Links: ASM and IDSA launch the Interdisciplinary Meeting on Antimicrobial Resistance and Innovation (IMARI) in 2026 Watch this session on YouTube This episode is brought to you by the Antimicrobial Agents and Chemotherapy Journal.  Visit asm.org/aac to browse issues and/or submit a manuscript. If you plan to publish in AAC, ASM Members get up to 50% off publishing fees. Visit asm.org/joinasm to sign up.

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• Updated FDA Recognition of CLSI Breakpoints (JCM ed.)

  Oversight and guidance for performing antibiotic susceptibility testing can be bewildering. There is an alphabet soup of agencies and bodies involved: FDA, CLSI, and USCAST, to name a few here in the US. How does the Food and Drug Administration, which has regulatory authority over AST, work with a nimble group like the Clinical Laboratory Standards Institute?   Guests: Romney Humphries, Ph.D., D(ABMM), M(ASCP) Patricia Simner, Ph.D., D(ABMM) Links: Major updates to FDA-recognized Clinical and Laboratory Standards Institute breakpoints are a win for the fight against antimicrobial resistance Join ASM for up to 50% off the publication fees when you publish in JCM or any of the ASM journals. Attend ASM Microbe This episode of Editors in Conversation is brought to you by the Journal of Clinical Microbiology and hosted by JCM Editor in Chief, Alex McAdam and Dr. Elli Theel. JCM is available at https://jcm.asm.org and on https://twitter.com/JClinMicro. Visit journals.asm.org/journal/jcm to read articles and/or submit a manuscript. Follow JCM on Twitter/𝕏 via @JClinMicro

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• Management of Pneumonia: Past, Present and Future

  In the last decade, there have been major changes in the approach of the treatment of pneumonia, in particular, with the availability of new diagnostic tools. Additionally, new drugs have been approved for the treatment of pneumonia. We discuss the approach to the management of pneumonia with a person who has spent most of his professional career working on this topic. Topics discussed: Definitions and nomenclature of pneumonia and evolution of these terms Changes in the diagnosis of pneumonia Ttherapeutic changes and future approaches for the treatment of pneumonia. Guest: Daniel M Musher, M.D. Links: ASM and IDSA launch the Interdisciplinary Meeting on Antimicrobial Resistance and Innovation (IMARI) in 2026 This episode is brought to you by the Antimicrobial Agents and Chemotherapy Journal.  Visit asm.org/aac to browse issues and/or submit a manuscript. If you plan to publish in AAC, ASM Members get up to 50% off publishing fees. Visit asm.org/joinasm to sign up.

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• Show Me the Light! Uv Light for Cyclospora

  Picture this, you wake up one morning with nausea, body aches, abdominal pain, and despite sleeping all night, you are exhausted. You then find yourself running to the restroom with watery and somewhat explosive diarrhea. You think to yourself – what could this be? Well, if the year was 2023, in the summer and you happen to live in Texas, chances were somewhat high that you had probably had cyclosporiasis.  And today, we are going to talk about this particular parasite and focus in on what our options are for detecting it given that it is not routinely picked up on O&P exams. And while there are molecular panels out there that include Cyclospora as a target, as our speakers will share, there is an easier and cheaper approach we can consider to quickly ID this pathogen. Guests: Dr. Angela Ma. Public Health Ontario and Assistant Professor at the University of Toronto Dr. Marc Couturier. Drector of the clinical microbiology lab at NorDx lab at MaineHealth in Scarborough, Maine Links: Shedding new light on Cyclospora: how the use of ultraviolet fluorescence microscopy can improve diagnosis of cyclosporiasis Join ASM for up to 50% off the publication fees when you publish in JCM or any of the ASM journals. Attend ASM Microbe This episode of Editors in Conversation is brought to you by the Journal of Clinical Microbiology and hosted by JCM Editor in Chief, Alex McAdam and Dr. Elli Theel. JCM is available at https://jcm.asm.org and on https://twitter.com/JClinMicro. Visit journals.asm.org/journal/jcm to read articles and/or submit a manuscript. Follow JCM on Twitter/𝕏 via @JClinMicro

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• Best Papers in the Journal of Clinical Microbiology, 2024

  The past year in Clinical Microbiology, as seen through the lens of the Journal of Clinical Microbiology. Four JCM editors have each selected a paper they consider to be among the “best” we published in 2024. Of course there are no objective criteria for what makes a paper the “best.” So, by “best,” we mean “a paper that I find exciting.” View this episode: https://www.youtube.com/watch?v=fK9ZqZUrDiY Guests: Patricia Simner, Ph.D., D(ABMM), Johns Hopkins University School of Medicine Romney Humphries, Ph.D., D(ABMM), M(ASCP), Vanderbilt University Medical Center Links: Wood RC, Luabeya AK, Dragovich RB, Olson AM, Lochner KA, Weigel KM, Codsi R, Mulenga H, de Vos M, Kohli M, Penn-Nicholson A, Hatherill M, Cangelosi GA. 2024. Diagnostic accuracy of tongue swab testing on two automated tuberculosis diagnostic platforms, Cepheid Xpert MTB/RIF Ultra and Molbio Truenat MTB Ultima. J Clin Microbiol 62:e00019-24. Rodino KG, Luethy PM, Abbott AN, Bender JM, Eberly AR, Gitman M, Leber A, Dien Bard J, . 2024. Defining the value of medical microbiology consultation. J Clin Microbiol 62:e00359-24. Giske CG, Bressan M, Fiechter F, Hinic V, Mancini S, Nolte O, Egli A. 2024. GPT-4-based AI agents—the new expert system for detection of antimicrobial resistance mechanisms?. J Clin Microbiol 62:e00689-24. Bloomfield M, van der Werff K, Todd S, Bocacao M, Reed H, Balm M, Blackmore T. 2024. An exception-reporting approach for wound swab culture: effect on post-report antibiotic initiation. J Clin Microbiol 62:e00342-24. Join ASM for up to 50% off the publication fees when you publish in JCM or any of the ASM journals. Attend ASM Microbe This episode of Editors in Conversation is brought to you by the Journal of Clinical Microbiology and hosted by JCM Editor in Chief, Alex McAdam and Dr. Elli Theel. JCM is available at https://jcm.asm.org and on https://twitter.com/JClinMicro. Visit journals.asm.org/journal/jcm to read articles and/or submit a manuscript. Follow JCM on Twitter/𝕏 via @JClinMicro

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