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JACC Specialty Journals

American College of Cardiology

Salute e benessere Scienze

Ultimo episodio

1873 episodi

The Transmural Activation Interval in Dilated Cardiomyopathy: A New Mapping Tool for Intramural VT Substrates | JACC: Clinical Electrophysiology
18/02/2026 | 4 min
Commentary by JACC: Clinical Electrophysiology Deputy Editor Francis Marchlinski, MD.
CRISPR/Cas9 screens implicate RARA and SPNS1 in doxorubicin cardiotoxicity | JACC: CardioOncology
17/02/2026 | 3 min
Researchers used genome‑wide CRISPR/Cas9 loss‑of‑function screens in cardiomyocytes to identify RARA and SPNS1 as key modulators of doxorubicin cardiotoxicity, highlighting pathways that influence both injury susceptibility and intracellular drug handling. Activation of RARA reduced toxicity without impairing anticancer effects, while SPNS1 loss caused harmful drug accumulation, offering new mechanistic insights and potential therapeutic targets.
Atrial Fibrillation Following Autologous Stem Cell Transplantation in Multiple Myeloma: Incidence, Predictors, and Prognostic Impact | JACC: CardioOncology
17/02/2026 | 3 min
This study of 801 multiple myeloma patients found that atrial fibrillation occurred in 5.5% within 90 days after autologous stem cell transplantation—nearly double previously reported rates—indicating disease‑specific risks. AF strongly predicted mortality from non‑relapse causes and may serve as a marker of physiological vulnerability, emphasizing the value of expanded pre‑transplant cardiac assessment and monitoring.
Polygenic risk for cardiometabolic and cardiovascular disease in a multi-ethnic cohort of breast cancer survivors | JACC: CardioOncology
17/02/2026 | 3 min
Polygenic risk scores showed associations with several cardiometabolic outcomes in breast cancer survivors but did not improve prediction beyond traditional clinical factors. Their performance varied across ancestry groups and was weakened in patients exposed to cardiotoxic therapies, highlighting limits of current genetic risk tools.
Systemic Manifestations and Mortality Risk in Transthyretin V142I Variant Carriers: A Million Veteran Program Analysis | JACC: CardioOncology
17/02/2026 | 3 min
This study analyzes over 2,600 transthyretin V142I variant carriers in the Million Veteran Program and finds significantly elevated risks of heart failure, cardiomyopathy, arrhythmias, neuropathy, and musculoskeletal complications compared with matched controls. Despite these risks, amyloidosis was rarely diagnosed clinically, underscoring major gaps in recognition and the need for earlier identification and multidisciplinary intervention.

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Su JACC Specialty Journals

In this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.

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Salute e benessere Scienze Scienze biologiche Medicina