NEJM This Week

This week, we feature new research on gene-edited therapies for children with β-thalassemia and sickle cell disease, treatment for membranous nephropathy, coronary revascularization after myocardial infarction, and an outbreak of severe methemoglobinemia. We review treatment decisions in multiple myeloma, follow a case of man with fever and rash, and report on psychedelic drug development. Perspectives address preventive care, AI-assisted translation, barriers to health care access, and the long shadow of Bedlam.

This week, we feature new research on acute myeloid leukemia, achondroplasia, pediatric septic shock, and RAS-mutant lung cancer. We also review the evaluation and management of pulmonary nodules and follow a diagnostic case of recurrent fractures. Perspectives explore reproductive health care, the human–animal bond in health care access, and on creating space for patients’ voices in clinical decision making.

This week, we feature new research on acute respiratory failure, wheezing in childhood, lung cancer, and obesity. We review myeloproliferative neoplasms and follow a diagnostic case of a patient with myasthenia gravis who developed dyspnea and weakness. Perspectives explore medical marijuana research, AI in clinical care, sexual and gender minority health research, and the Perspectives Editor saying goodbye.

This week, we feature new research on polymyalgia rheumatica, hypercholesterolemia, prostate cancer, and multiple myeloma. We review evidence-based strategies for tobacco cessation, and follow a case of a woman with nausea, dizziness, and metabolic acidosis. We discuss recent advances in gene editing for rare metabolic diseases. Perspectives address HIV care, health care quality, medical ethics, and finding resilience in the face of serious illness.

This week, we feature new research on chronic kidney disease, high-risk prostate cancer, peripheral artery disease, and oxygen therapy after cardiac arrest. We review the evaluation and management of syncope, follow a challenging case of immune-related inflammatory illness, and report on Perspectives exploring pandemic preparedness, the Bundibugyo Ebola outbreak, and physician mental health.