In this inaugural episode of the new podcast series produced by ACC’s Interventional Member Section, Dr. Poonam Velagapudi is joined by featured guests Drs. Debabrata Dash and Thomas Cuisset to discuss the Highlights from EuroPCR 2025. Explore key insights from the 4D-ACS trial, followed by a discussion on its practical impact in clinical settings. The discussants examine the FAITAVI trial, highlighting major findings and their influence on procedural decision-making. A recent meta-analysis is also reviewed, with commentary on how the collective evidence may shape real-world interventional strategies. Tune in for a dynamic exchange on cutting-edge trials and their implications for the cath lab. Related References: The FAITAVI trial: angiography versus physiology-guided PCI in patients undergoing TAVI – 12-month follow-up data (PCR Online). 2025. Available at: https://www.pcronline.com/News/PCR-Press-Releases/2025/EuroPCR-2025-The-FAITAVI-trial-angiography-versus-physiology-guided-PCI-in-patients-undergoing-TAVI-12-month-follow-up-data. Accessed 6/24/25. Ribichini F, Pesarini G, Fabris T, et al. A randomised multicentre study of angiography- versus physiologyguided percutaneous coronary intervention in patients with coronary artery disease undergoing TAVI: design and rationale of the FAITAVI trial. EuroIntervention. 2024 Apr 15;20(8):e504-e510. doi: 10.4244/EIJ-D-23-00679. Jang Y, Park SD, Lee JP, et al. One-month dual antiplatelet therapy followed by prasugrel monotherapy at a reduced dose: the 4D-ACS randomised trial. EuroIntervention. 2025 May 21:EIJ-D-25-00331. doi: 10.4244/EIJ-D-25-00331. Subscribe to CardiaCast | Claim CME Credit
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Moving the Needle: Clinical Strategies focusing on Controlling LDL-C
In this episode of CardiaCast, Drs. Erin Michos and Joseph Saseen discuss the underuse of lipid-lowering therapies in patients with cardiovascular risk, despite strong evidence and updated guidelines. They highlight the role of bempedoic acid as a non-statin option, especially for statin-intolerant patients. The conversation emphasizes team-based care, shared decision-making, and strategies to navigate insurance barriers to improve LDL-C management. This podcast is part of Bempedoic Acid: New Evidence Transforming the LDL-C Treatment Landscape grant initiative. Educational grant support is provided by Esperion. Related References Nelson A, Haynes K, Shambhu S, et al. High-intensity statin use among patients with atherosclerosis in the U.S. J Am Coll Cardiol. 2022;79(18):1802–1813. doi:10.1016/j.jacc.2022.02.048 Cannon CP, de Lemos JA, Rosenson RS, et al. Use of lipid-lowering therapies over 2 years in GOULD, a registry of patients with atherosclerotic cardiovascular disease in the US. JAMA Cardiol. 2021;6(9):1060–1068. doi:10.1001/jamacardio.2021.1810 Worledge EA, Billups SJ, Titus OJ, Saseen JJ. Achievement of low-density lipoprotein cholesterol thresholds in very high-risk atherosclerotic cardiovascular disease. J Clin Lipidol. Published online April 11, 2025. doi:10.1016/j.jacl.2025.04.186 Subscribe to CardiaCast
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20:33
SCAI 2025 Think Tank Session Highlights: Radiation Protection and Team Well-Being
In this episode Drs. Poonam Velagapudi, Saraschandra Vallabhajosyula, and James Hermiller explore the critical topic of occupational safety in the cath lab. While healthcare providers focus on treating patients, their work environment can put their own health at risk—particularly long-term impact of wearing heavy lead protection. Drawing from discussions at the Society for Cardiovascular Angiography & Interventions (SCAI) 2025 Think Tank Sessions, the episode highlights data on lead-free and reduced-lead solutions aimed at preventing back pain and injury among cardiac catheterization operators. Tune in for a timely conversation on protecting the well-being of the heart team. Related References Strepkos D, Rempakos A, Alexandrou M, et al. How to Improve Radiation Protection in Interventional Cardiology Procedures. Circ Cardiovasc Interv. 2025;18(4):e014808. doi:10.1161/CIRCINTERVENTIONS.124.014808 Women in Innovations (WIN) Radiation Safety (SCAI website). 2025. Available at: https://scai.org/membership/career-development/women-innovations-win/win-radiation-safety . Accessed 06/17/25. SCAI Highlights Cath Lab Radiation and Orthopaedic Hazards (Cardiovascular News website). Available at: https://cardiovascularnews.com/scai-highlights-cath-lab-radiation-and-orthopaedic-hazards/. Accessed 06/17/25. Occupational Health Hazards in the Cardiac Catheterization Laboratory (SCAI website). 2025. Available at: https://scai.org/occupational-health-hazards-cardiac-catheterization-laboratory . Accessed 06/17/25. Subscribe to CardiaCast | Claim CME Credit
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Conversations in Heart Failure “Extrapolate with Caution: A STEMI Shock Reality Check”
In this episode, Drs. Jenna Skowronski, Francesco Castagna and Saraschandra Vallabhajosyula unpack how assumptions drawn from ST-segment elevation myocardial infarction (STEMI) data may be leading us astray in broader shock management—and what that means for patient outcomes, clinical decision-making, and future research. Why do we keep applying STEMI solutions to non-STEMI problems? Are we oversimplifying cardiogenic shock? And what does the real-world data actually tell us? Join us for a candid, fast-paced conversation that challenges dogma, calls for nuance, and might just change the way you approach shock. Related References: Møller JE, Engstrøm T, Jensen LO, et al. Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock. N Engl J Med. 2024;390(15):1382-1393. doi:10.1056/NEJMoa2312572. Kochar A, Vallabhajosyula S, John K, et al. Factors associated with acute limb ischemia in cardiogenic shock and downstream clinical outcomes: Insights from the Cardiogenic Shock Working Group. J Heart Lung Transplant. 2024;43(11):1846-1856. doi:10.1016/j.healun.2024.06.012. Subscribe to CardiaCast | Claim CME Credit
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Pharmacologic Interventions to Lower hs-CRP
n this episode, Drs. Brittany Weber and Michael Garshick discuss “Pharmacologic Interventions to Lower hs-CRP.” This podcast is part of the Inflammation in Cardiovascular Health: Raising Awareness of the Increasing Role of hs-CRP grant initiative. Educational support for this initiative is provided by Novo Nordisk. Click here to learn more. Related References: Nidorf SM, Fiolet ATL, Mosterd A, et al; LoDoCo2 Trial Investigators. Colchicine in Patients with Chronic Coronary Disease. N Engl J Med. 2020;383(19):1838-1847. Ridker PM. From CANTOS to CIRT to COLCOT to Clinic: Will All Atherosclerosis Patients Soon Be Treated With Combination Lipid-Lowering and Inflammation-Inhibiting Agents? Circulation. 2020;141(10):787-789. Ridker PM. From RESCUE to ZEUS: Will interleukin-6 inhibition with ziltivekimab prove effective for cardiovascular event reduction? Cardiovasc Res. 2021;117(11):e138-e140. Ridker PM, Bhatt DL, Pradhan AD, et al; PROMINENT, REDUCE-IT, and STRENGTH Investigators. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet. 2023;401(10384):1293-1301. Ridker PM, Moorthy MV, Cook NR, et al. Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women. N Engl J Med. 2024;391(22):2087-2097. Tardif JC, Kouz S, Waters DD, et al. Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. N Engl J Med. 2019;381(26):2497-2505. Subscribe to CardiaCast
This occasional series from the American College of Cardiology offers the latest in clinical education and features an exploration of current research and interviews with cardiovascular experts.
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