Associate Editor Elie Al Kazzi, MD, MPH and Vasantham Chaudhary, MD discuss "Appendicectomy versus switching to a JAK inhibitor in inducing remission in patients with active ulcerative colitis after biologic therapy failure (COSTA): 1-year results of a multicentre, prospective, cohort study, by Visser E, Reijntjes MA, Heuthorst L, et al. Published in Lancet Gastroenterol Hepatol. 2026 Mar;11(3):190-203.